| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38477419 | Therapeutic applicability of cannabidiol and other phytocannabinoids in epilepsy, multiple sclerosis and Parkinson's disease and in comorbidity with psychiatric disorders |
| Curcumin | 📋 | ✍ | ⛔ | | 37781812 | Amendment of Altered Immune Response by Curcumin in Drosophila Model of Huntington's Disease |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38684734 | Resveratrol and 1,25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic benefits |
| Resveratrol | 📋 | ✍ | ⛔ | | 38684734 | Resveratrol and 1,25-dihydroxyvitamin D decrease Lingo-1 levels, and improve behavior in harmaline-induced Essential tremor, suggesting potential therapeutic benefits |
| Melatonin | 📋 | ✍ | ⛔ | | 38259379 | Neuroprotective Potential of Melatonin: Evaluating Therapeutic Efficacy in Alzheimer's and Parkinson's Diseases |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38105596 | Ginsenoside Rk1 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease via activating silence information regulator 3-mediated Nrf2/HO-1 signaling pathway |
| Quercetin | 📋 | ✍ | ⛔ | | 38682342 | Effects of quercetin in preclinical models of Parkinson's disease: A systematic review |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38116567 | Ginkgo biloba Efficacy in the Treatment of Drug-Induced Parkinsonism: A Randomized Clinical Trial |
| CoQ10 | 📋 | ✍ | ⛔ | | 38673663 | Primary Coenzyme Q10 Deficiency-Related Ataxias |
| EGCG | 📋 | ✍ | ⛔ | | 38526966 | Neuroprotective effect of green tea extract (-)-epigallocatechin-3-gallate in a preformed fibril-induced mouse model of Parkinson's disease |
| Salidroside | 📋 | | | | 38424396 | Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in Parkinson's Disease |
| Vitamin E | 📋 | ✍ | ⛔ | | 38249609 | Dietary vitamin E intake and risk of Parkinson's disease: a cross-sectional study |
| Baicalein | 📋 | ✍ | ⛔ | | 38460310 | Insights into dietary phytochemicals targeting Parkinson's disease key genes and pathways: A network pharmacology approach |
| Caffeine | 📋 | ✍ | ⛔ | | 38513162 | Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort |
| Berberine | 📋 | ✍ | ⛔ | | 36907500 | New insights into the role of berberine against 3-nitropropionic acid-induced striatal neurotoxicity: Possible role of BDNF-TrkB-PI3K/Akt and NF-κB signaling |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 38201915 | Ellagic Acid Prevents α-Synuclein Spread and Mitigates Toxicity by Enhancing Autophagic Flux in an Animal Model of Parkinson's Disease |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 37751556 | α-lipoic acid ameliorates consequences of copper overload by up-regulating selenoproteins and decreasing redox misbalance |
| Vitamin C | 📋 | ✍ | ⛔ | | 33408141 | Dietary Antioxidants and the Risk of Parkinson Disease: The Swedish National March Cohort |
| Astragalosides | 📋 | ✍ | ⛔ | | 37603153 | Astragaloside IV Inhibits Rotenone-Induced α-syn Presentation and the CD4 T-Cell Immune Response |
| Fisetin | 📋 | ✍ | ⛔ | | 37886009 | Evaluation of fisetin as a potential inducer of mitochondrial biogenesis in SH-SY5Y neuronal cells |
| Naringenin | 📋 | ✍ | ⛔ | | 37796415 | Naringenin, a Functional Food Component, Improves Motor and Non-Motor Symptoms in Animal Model of Parkinsonism Induced by Rotenone |
| Rutin | 📋 | ✍ | ⛔ | | 38256111 | Effect of the Flavonoid Rutin on the Modulation of the Myenteric Plexuses in an Experimental Model of Parkinson's Disease |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 38602571 | Parkinson's disease and vitamins: a focus on vitamin B12 |
| Ashwagandha | 📋 | ✍ | ⛔ | | 35111460 | Withania somnifera as an Adjunctive Treatment for Refractory Restless Legs Syndrome in Parkinson's Disease: A Case Report |
| Chrysin | 📋 | ✍ | ⛔ | | 35118868 | Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson's Disease |
| Phytochemicals | 📋 | | | | 38005310 | Emerging Role of Plant-Based Bioactive Compounds as Therapeutics in Parkinson's Disease |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 30890473 | Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson's disease mouse model: Endothelial and microglial effects |
| Carvacrol | 📋 | ✍ | ⛔ | | 38649135 | Neuroprotective role of Carvacrol via Nrf2/HO-1/NLRP3 axis in Rotenone-induced PD mice model |
| Crocin | 📋 | ✍ | ⛔ | | 38356604 | Crocin attenuates the lipopolysaccharide-induced neuroinflammation via expression of AIM2 and NLRP1 inflammasome in an experimental model of Parkinson's disease |
| Food | 📋 | | | | 37431106 | A comprehensive examination of the evidence for whole of diet patterns in Parkinson's disease: a scoping review |
| Fucoidan | 📋 | ✍ | ⛔ | | 32630523 | Protective Effect of Fucoidan against MPP +-Induced SH-SY5Y Cells Apoptosis by Affecting the PI3K/Akt Pathway |
| Hesperidin | 📋 | ✍ | ⛔ | | 38423185 | Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster |
| L-Theanine | 📋 | ✍ | ⛔ | | 37191688 | L-theanine attenuates LPS-induced motor deficit in experimental rat model of Parkinson's disease: emphasis on mitochondrial activity, neuroinflammation, and neurotransmitters |
| Piperine | 📋 | ✍ | ⛔ | | 38158101 | Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 36587225 | Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial |
| 5-HTP | 📋 | ✍ | ⛔ | | 36918741 | 5-Hydroxytryptophan Reduces Levodopa-Induced Dyskinesia via Regulating AKT/mTOR/S6K and CREB/ΔFosB Signals in a Mouse Model of Parkinson's Disease |
| Astaxanthin | 📋 | ✍ | ⛔ | | 37708917 | Astaxanthin ameliorates dopaminergic neuron damage in paraquat-induced SH-SY5Y cells and mouse models of Parkinson's disease |
| Echinacoside | 📋 | | | | 38000105 | Echinacoside exerts neuroprotection via suppressing microglial α-synuclein/TLR2/NF-κB/NLRP3 axis in parkinsonian models |
| Mangiferin | 📋 | | ⛔ | | 38142926 | Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38678615 | Omega-3 polyunsaturated fatty acids play a protective role in a mouse model of Parkinson's disease by increasing intestinal inducible Treg cells |
| Puerarin | 📋 | ✍ | ⛔ | | 32763437 | Puerarin suppresses MPP +/MPTP-induced oxidative stress through an Nrf2-dependent mechanism |
| TUDCA | 📋 | ✍ | ⛔ | | 33345721 | Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson's disease |
| Butyrate | 📋 | | ⛔ | | 38694925 | Buty and the beast: the complex role of butyrate in Parkinson's disease |
| Creatine | 📋 | ✍ | ⛔ | | 38262563 | Creatine supplementation with exercise reduces α-synuclein oligomerization and necroptosis in Parkinson's disease mouse model |
| Flavonoids | 📋 | | ⛔ | | 38039600 | Dietary flavonoids may have a protective and therapeutic effect in Parkinson disease: A systematic review |
| Luteolin | 📋 | ✍ | ⛔ | | 38125952 | The flavonoid luteolin reduces mutant huntingtin aggregation and cytotoxicity in huntingtin-mutated neuroblastoma cells |
| Medicinal Plants | 📋 | | | | 36299886 | Multifunctional role of natural products for the treatment of Parkinson's disease: At a glance |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 38016950 | NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease |
| Pine Bark | 📋 | ✍ | ⛔ | | 36153882 | Pycnogenol® supplementation alleviates symptoms of Parkinson's disease with mild cognitive impairment |
| Cinnamon | 📋 | ✍ | ⛔ | | 34770830 | Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP +-Induced Apoptosis in a Cell Culture Model of Parkinson's Disease |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 37712262 | [Dihydromyricetin alleviates pyroptosis and necroptosis in mice with MPTP-induced chronic Parkinson's disease by inducing autophagy] |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 38604452 | The neuroprotective effects of ferulic acid in toxin-induced models of Parkinson's disease: A review |
| Ginkgolides | 📋 | | | | 36863713 | Ginkgolide A improves the pleiotropic function and reinforces the neuroprotective effects by mesenchymal stem cell-derived exosomes in 6-OHDA-induced cell model of Parkinson's disease |
| Ginseng | 📋 | ✍ | ⛔ | | 34580047 | Korean red ginseng decreases 1-methyl-4-phenylpyridinium-induced mitophagy in SH-SY5Y cells |
| Hydroxytyrosol | 📋 | | | | 34260002 | Antioxidant Effect of Hydroxytyrosol, Hydroxytyrosol Acetate and Nitrohydroxytyrosol in a Rat MPP + Model of Parkinson's Disease |
| Licorice Root | 📋 | ✍ | ⛔ | | 35307886 | Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)-mediated neuroprotection in a rotenone-induced cellular model of Parkinson's disease by restoring the mTORC1-AMPK1 axis in autophagic regulation |
| Metformin | 📋 | ✍ | ⛔ | | 38566081 | Metformin normalizes mitochondrial function to delay astrocyte senescence in a mouse model of Parkinson's disease through Mfn2-cGAS signaling |
| Pomegranate | 📋 | | ⛔ | | 38001844 | Pomegranate Extract Administration Reverses Loss of Motor Coordination and Prevents Oxidative Stress in Cerebellum of Aging Mice |
| Probiotics | 📋 | ✍ | ⛔ | | 38314132 | Relationship among Parkinson's disease, constipation, microbes, and microbiological therapy |
| Silibinin | 📋 | ✍ | | | 37480498 | Oral Administration of Silybin Protects Against MPTP-Induced Neurotoxicity by Reducing Pro-inflammatory Cytokines and Preserving BDNF Levels in Mice |
| Sulforaphane | 📋 | ✍ | ⛔ | | 37429146 | Screening of H2S donors with a red emission mitochondria-targetable fluorescent probe: Toward discovering a new therapeutic strategy for Parkinson's disease |
| Vitamin A | 📋 | ✍ | ⛔ | | 38040269 | Supplementation with Vitamins D3 and A Mitigates Parkinsonism in a Haloperidol Mice Model |
| Zinc | 📋 | ✍ | ⛔ | | 36913450 | Zinc Deficiency Exacerbates Behavioral Impediments and Dopaminergic Neuron Degeneration in a Mouse Model of Parkinson Disease |
| Andrographolide | 📋 | | | | 37239873 | Neuroprotection of Andrographolide against Neurotoxin MPP+-Induced Apoptosis in SH-SY5Y Cells via Activating Mitophagy, Autophagy, and Antioxidant Activities |
| Antioxidants | 📋 | | ⛔ | | 37513820 | A Review on Natural Antioxidants for Their Role in the Treatment of Parkinson's Disease |
| Asiatic Acid | 📋 | | | | 30971058 | Asiatic Acid Protects Dopaminergic Neurons from Neuroinflammation by Suppressing Mitochondrial Ros Production |
| Asiaticoside | 📋 | | | | 38471370 | Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation |
| Bee Venom | 📋 | ✍ | ⛔ | | 36280441 | Melittin ameliorates motor function and prevents autophagy-induced cell death and astrogliosis in rat models of cerebellar ataxia induced by 3-acetylpyridine |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 36359390 | Beta-Boswellic Acid Reverses 3-Nitropropionic Acid-Induced Molecular, Mitochondrial, and Histopathological Defects in Experimental Rat Model of Huntington's Disease |
| Cordycepin | 📋 | | | | 38479634 | Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 36555817 | The Polyunsaturated Fatty Acid EPA, but Not DHA, Enhances Neurotrophic Factor Expression through Epigenetic Mechanisms and Protects against Parkinsonian Neuronal Cell Death |
| Genistein | 📋 | ✍ | ⛔ | | 37992314 | Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation |
| Hesperetin | 📋 | | | | 38423185 | Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster |
| Morin | 📋 | | | | 38141855 | Morin suppresses mTORc1/IRE-1α/JNK and IP3R-VDAC-1 pathways: Crucial mechanisms in apoptosis and mitophagy inhibition in experimental Huntington's disease, supported by in silico molecular docking simulations |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 37507913 | Targeting the Cysteine Redox Proteome in Parkinson's Disease: The Role of Glutathione Precursors and Beyond |
| Nobiletin | 📋 | ✍ | | | 31295812 | Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer's Disease and Parkinson's Disease |
| Oleuropein | 📋 | | | | 36774383 | Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease via BDNF/CREB/Akt pathway |
| Saffron | 📋 | ✍ | ⛔ | | 34224829 | Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models |
| Safranal | 📋 | | | | 38683404 | Safranal exerts a neuroprotective effect on Parkinson's disease with suppression of NLRP3 inflammation activation |
| Silymarin | 📋 | ✍ | ⛔ | | 36568269 | Neuroprotective effect of silymarin against 3-Nitropropionic acid-induced neurotoxicity in rats |
| Spikenard | 📋 | ✍ | ⛔ | | 37559448 | Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways |
| Tangeretin | 📋 | | | | 31039425 | Role of tangeritin against cognitive impairments in transgenic Drosophila model of Parkinson's disease |
| Trehalose | 📋 | | ⛔ | | 35618982 | Trehalose ameliorates prodromal non-motor deficits and aberrant protein accumulation in a rotenone-induced mouse model of Parkinson's disease |
| Anethole | 📋 | | | | 37972114 | Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal α-synuclein and oxidative stress in rotenone-induced Parkinson's disease of male rats |
| Apigenin | 📋 | ✍ | ⛔ | | 35698811 | Apigenin alleviates neuroinflammation in a mouse model of Parkinson's disease |
| Artemisinin | 📋 | | | | 38056239 | Artemisinin protects dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in a mouse model of Parkinson's disease |
| Baicalin | 📋 | ✍ | ⛔ | | 38016618 | Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease |
| Bee Propolis | 📋 | ✍ | ⛔ | | 36313332 | Propolis induces cardiac metabolism changes in 6-hydroxydopamine animal model: A dietary intervention as a potential cardioprotective approach in Parkinson's disease |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 36253999 | Dietary β-carotene and vitamin A and risk of Parkinson disease: A protocol for systematic review and meta-analysis |
| CAPE | 📋 | | | | 37313025 | Caffeic Acid Phenethyl Ester With Mesenchymal Stem Cells Improves Behavioral and Histopathological Changes in the Rat Model of Parkinson Disease |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 37544423 | Neuroprotective effect of chlorogenic acid on Parkinson's disease like symptoms through boosting the autophagy in zebrafish |
| Cocoa | 📋 | ✍ | ⛔ | | 36009556 | Cocoa Extract Provides Protection against 6-OHDA Toxicity in SH-SY5Y Dopaminergic Neurons by Targeting PERK |
| Daidzein | 📋 | ✍ | ⛔ | | 38679467 | Daidzein ameliorates nonmotor symptoms of manganese-induced Parkinsonism in zebrafish model: Behavioural and biochemical approach |
| Dioscin | 📋 | | | | 38024855 | Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 33279658 | Contribution of DHA diols (19,20-DHDP) produced by cytochrome P450s and soluble epoxide hydrolase to the beneficial effects of DHA supplementation in the brains of rotenone-induced rat models of Parkinson's disease |
| Elderberry | 📋 | ✍ | ⛔ | | 38401660 | Elderberry diet enhances motor performance and reduces neuroinflammation-induced cell death in cerebellar ataxia rat models |
| Fish Oil | 📋 | ✍ | ⛔ | | 38348197 | Fish oil supplementation, physical activity and risk of incident Parkinson's disease: results of longitudinal analysis from the UK Biobank |
| Gallic Acid | 📋 | | ⛔ | | 38296489 | Neuroprotective effect of gallic acid in mice with rotenone-induced neurodegeneration |
| Goji Berry | 📋 | ✍ | ⛔ | | 36322321 | Neuroprotective Effects of Lycium Barbarum Fruit Extract on Pink1B9Drosophila Melanogaster Genetic Model of Parkinson's Disease |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 33207644 | Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice |
| Hyperoside | 📋 | | | | 36576692 | Neuroprotective effect of hyperoside in MPP+/MPTP -induced dopaminergic neurodegeneration |
| Icariin | 📋 | ✍ | | | 38176950 | Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2 |
| Isoliquiritigenin | 📋 | | | | 36484427 | Isoliquiritigenin inhibits microglia-mediated neuroinflammation in models of Parkinson's disease via JNK/AKT/NFκB signaling pathway |
| Kaempferol | 📋 | ✍ | ⛔ | | 36469163 | Kaemperfol Protects Dopaminergic Neurons by Promoting mTOR-Mediated Autophagy in Parkinson's Disease Models |
| Lycopene | 📋 | ✍ | ⛔ | | 28386384 | Association of serum carotenoid, retinol, and tocopherol concentrations with the progression of Parkinson's Disease |
| Magnesium | 📋 | ✍ | ⛔ | | 36587225 | Therapeutic effects of magnesium and vitamin B6 in alleviating the symptoms of restless legs syndrome: a randomized controlled clinical trial |
| Paeoniflorin | 📋 | | | | 36881748 | Paeoniflorin protects 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mice by inhibiting oxidative stress and neuronal apoptosis through activating the Nrf2/HO-1 signaling pathway |
| Peony | 📋 | | ⛔ | | 37838295 | Total Glucosides of White Paeony Capsule ameliorates Parkinson's disease-like behavior in MPTP-induced mice model by regulating LRRK2/alpha-synuclein signaling |
| Polyphenols | 📋 | | | | 37224894 | Antiparkinsonian Effects of Polyphenols: A Narrative Review with a Focus on the Modulation of the Gut-brain Axis |
| PQQ | 📋 | ✍ | ⛔ | | 32977419 | Pyrroloquinoline Quinone Inhibits Rotenone-Induced Microglia Inflammation by Enhancing Autophagy |
| Punicalagin | 📋 | ✍ | ⛔ | | 37896179 | Punicalagin's Protective Effects on Parkinson's Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway |
| Rapamycin | 📋 | ✍ | | | 37823007 | Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 36145248 | Ganoderma lucidum Modulates Inflammatory Responses following 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Administration in Mice |
| Rosmarinic Acid | 📋 | ✍ | | | 36079767 | Rosmarinic Acid Attenuates Rotenone-Induced Neurotoxicity in SH-SY5Y Parkinson's Disease Cell Model through Abl Inhibition |
| Schisandra | 📋 | ✍ | ⛔ | | 36899922 | Micrandilactone C, a Nortriterpenoid Isolated from Roots of Schisandra chinensis, Ameliorates Huntington's Disease by Inhibiting Microglial STAT3 Pathways |
| Selenium | 📋 | ✍ | ⛔ | | 37864700 | Association between blood selenium with parkinson's disease in the US (NHANES 2011-2020) |
| Telmisartan | 📋 | | ⛔ | | 38419447 | Telmisartan Protects Mitochondrial Function, Gait, and Neuronal Apoptosis by Activating the Akt/GSK3β/PGC1α Pathway in an MPTP-Induced Mouse Model of Parkinson's Disease |
| Thymoquinone | 📋 | | ⛔ | | 38660812 | Thymoquinone ameliorates symptoms of Parkinson's disease in a 6-OHDA rat model by downregulation of miR-204-3p |
| Urolithins | 📋 | | | | 37508017 | Urolithin A in Health and Diseases: Prospects for Parkinson's Disease Management |
| Valerian Root | 📋 | ✍ | ⛔ | | 31909290 | "Effect of valerenic acid on neuroinflammation in a MPTP-induced mouse model of Parkinson's disease" |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 22610053 | High intake of folic acid or complex of B vitamins provides anti-Parkinsonism effect: no role for serum level of homocysteine |
| Acai Berry | 📋 | ✍ | ⛔ | | 35970975 | Açai Berry Mitigates Parkinson's Disease Progression Showing Dopaminergic Neuroprotection via Nrf2-HO1 Pathways |
| Atractylodes | 📋 | ✍ | ⛔ | | 35104500 | Atractylon, a novel dopamine 2 receptor agonist, ameliorates Parkinsonian like motor dysfunctions in MPTP-induced mice |
| Betulinic Acid | 📋 | | | | 36474564 | The effects of betulinic acid chronic administration on the motor, non-motor behaviors, and globus pallidus local field potential power in a rat model of hemiparkinsonism |
| Bilobalide | 📋 | | | | 36037147 | Targeting the differentiation of astrocytes by Bilobalide in the treatment of Parkinson's disease model |
| Black Tea | 📋 | ✍ | ⛔ | | 22138428 | Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease |
| Blackberry | 📋 | | ⛔ | | 30013404 | Effects of blackberry ( Morus nigra) fruit juice on levodopa-induced dyskinesia in a mice model of Parkinson's disease |
| Bromelain | 📋 | ✍ | ⛔ | | 34643923 | Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson's disease |
| Carnosic Acid | 📋 | | | | 34434108 | Carnosic Acid Alleviates Levodopa-Induced Dyskinesia and Cell Death in 6-Hydroxydopamine-lesioned Rats and in SH-SY5Y Cells |
| Carotenoids | 📋 | ✍ | ⛔ | | 32630250 | Dietary Antioxidants and Parkinson's Disease |
| Catechins | 📋 | | | | 35337893 | Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB, IκKB, and p53 genes in male Wistar rats |
| Chicoric Acid | 📋 | | | | 35216146 | Chicoric Acid Prevents Neuroinflammation and Neurodegeneration in a Mouse Parkinson's Disease Model: Immune Response and Transcriptome Profile of the Spleen and Colon |
| Cinnamaldehyde | 📋 | | | | 38621979 | [Improvement effect of cinnamaldehyde on reserpine-induced Parkinson's disease rat model] |
| Citicoline | 📋 | ✍ | ⛔ | | 33279231 | Citicoline as Adjuvant Therapy in Parkinson's Disease: A Systematic Review |
| Coconut Oil | 📋 | | ⛔ | | 36208039 | Neuroprotective role of coconut oil for the prevention and treatment of Parkinson's disease: potential mechanisms of action |
| Coffee | 📋 | ✍ | ⛔ | | 38513162 | Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort |
| Coptis Chinensis | 📋 | | ⛔ | | 38599826 | Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells |
| Coriander | 📋 | | ⛔ | | 35922685 | Heated Leaf Extract of Coriandrum sativum L. Protects Nigral Dopaminergic Degeneration in Rats |
| Crocetin | 📋 | | | | 34224829 | Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models |
| Dihydroquercetin | 📋 | | | | 38723817 | Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation |
| Folate | 📋 | ✍ | ⛔ | | 37735121 | Features of Plasma Homocysteine, Vitamin B12, and Folate in Parkinson's Disease: An Updated Meta-Analysis |
| Forskolin | 📋 | ✍ | ⛔ | | 36614135 | Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats |
| Frankincense | 📋 | ✍ | ⛔ | | 35804280 | Methanolic Extract of Boswellia serrata Gum Protects the Nigral Dopaminergic Neurons from Rotenone-Induced Neurotoxicity |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 35447917 | Fucoxanthin Prevents Long-Term Administration l-DOPA-Induced Neurotoxicity through the ERK/JNK-c-Jun System in 6-OHDA-Lesioned Mice and PC12 Cells |
| Galangin | 📋 | | | | 36015161 | Galangin Exhibits Neuroprotective Effects in 6-OHDA-Induced Models of Parkinson's Disease via the Nrf2/Keap1 Pathway |
| Garlic | 📋 | ✍ | ⛔ | | 36861262 | The Pharmacological Activity of Garlic ( Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential |
| Geniposide | 📋 | | | | 37451492 | Geniposide protects against neurotoxicity in mouse models of rotenone-induced Parkinson's disease involving the mTOR and Nrf2 pathways |
| Geranium | 📋 | | | | 37819493 | Therapeutic Effects of Geranium Oil in MPTP-Induced Parkinsonian Mouse Model |
| Gotu Kola | 📋 | ✍ | ⛔ | | 36150031 | Oral administration of hydroalcoholic extract of Centella asiatica ameliorates neurotoxicity and neurobehavioral deficits in 3-nitropropionic acid-induced Huntington's like symptoms in adult zebrafish |
| Green Tea | 📋 | ✍ | ⛔ | | 35719152 | Green Tea Intake and Parkinson's Disease Progression: A Mendelian Randomization Study |
| Irisin | 📋 | | | | 38134742 | Relationship of irisin with disease severity and dopamine uptake in Parkinson's disease patients |
| Iron | 📋 | ✍ | ⛔ | | 24198314 | Treatment of pediatric restless legs syndrome |
| Isoflavones | 📋 | ✍ | ⛔ | | 34854012 | Reversal of haloperidol-induced orofacial dyskinesia and neuroinflammation by isoflavones |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 34779137 | Effect of massage therapy with lavender oil on severity of restless legs syndrome and quality of life in hemodialysis patients |
| Licochalcones | 📋 | | | | 36672736 | Neuroprotective Effects of Licochalcone D in Oxidative-Stress-Induced Primitive Neural Stem Cells from Parkinson's Disease Patient-Derived iPSCs |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 37047062 | Hericium erinaceus Promotes Anti-Inflammatory Effects and Regulation of Metabolites in an Animal Model of Cerebellar Ataxia |
| Long Pepper | 📋 | | ⛔ | | 26232071 | Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury |
| Mangosteen | 📋 | ✍ | ⛔ | | 36552604 | Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson's Disease |
| Marigold | 📋 | ✍ | ⛔ | | 38268908 | Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease |
| Micronutrients | 📋 | | ⛔ | | 35526248 | The neuroprotective roles of Dietary Micronutrients on Parkinson's disease: a review |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 35630617 | Mucuna pruriens Seed Aqueous Extract Improved Neuroprotective and Acetylcholinesterase Inhibitory Effects Compared with Synthetic L-Dopa |
| Myricetin | 📋 | | ⛔ | | 35657723 | Myricetin inhibits α-synuclein amyloid aggregation by delaying the liquid-to-solid phase transition |
| Naringin | 📋 | ✍ | ⛔ | | 33523404 | Naringin Ameliorates Haloperidol-Induced Neurotoxicity and Orofacial Dyskinesia in a Rat Model of Human Tardive Dyskinesia |
| NMN | 📋 | ✍ | ⛔ | | 27035562 | NAMPT protects against 6-hydroxydopamine-induced neurotoxicity in PC12 cells through modulating SIRT1 activity |
| Nootkatone | 📋 | | | | 38001852 | Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson's Disease Mouse Model |
| Procyanidins | 📋 | | ⛔ | | 34770830 | Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP +-Induced Apoptosis in a Cell Culture Model of Parkinson's Disease |
| Salvianolic Acid | 📋 | | | | 33994527 | Salvianolic acid B protects against MPP+-induced neuronal injury via repressing oxidative stress and restoring mitochondrial function |
| Senolytics | 📋 | | | | 37840914 | Senolytic and senomorphic secondary metabolites as therapeutic agents in Drosophila melanogaster models of Parkinson's disease |
| Spirulina | 📋 | ✍ | ⛔ | | 26306668 | Neuroprotective effect of Spirulina fusiform and amantadine in the 6-OHDA induced Parkinsonism in rats |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 38387425 | The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats |
| Taurine | 📋 | ✍ | ⛔ | | 33998560 | Protective effect of caffeine and/or taurine on the 6-hydroxydopamine-induced rat model of Parkinson's disease: Behavioral and neurochemical evidence |
| Thymol | 📋 | ✍ | ⛔ | | 35144603 | Thymol protects against 6-hydroxydopamine-induced neurotoxicity in in vivo and in vitro model of Parkinson's disease via inhibiting oxidative stress |
| UDCA | 📋 | ✍ | ⛔ | | 38024855 | Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 36543778 | Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 34220485 | Niacin Enhancement for Parkinson's Disease: An Effectiveness Trial |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 38045419 | Biotin rescues manganese-induced Parkinson's disease phenotypes and neurotoxicity |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 32862152 | The association of serum vitamin K2 levels with Parkinson's disease: from basic case-control study to big data mining analysis |
| Vitamins | 📋 | | | | 37509049 | What Dietary Vitamins and Minerals Might Be Protective against Parkinson's Disease? |
| Walnut | 📋 | | ⛔ | | 26784178 | In Vitro and in Vivo Neuroprotective Effects of Walnut (Juglandis Semen) in Models of Parkinson's Disease |
| Wormwood | 📋 | ✍ | ⛔ | | 35752074 | Artemisia Leaf Extract protects against neuron toxicity by TRPML1 activation and promoting autophagy/mitophagy clearance in both in vitro and in vivo models of MPP+/MPTP-induced Parkinson's disease |
| Acacetin | 📋 | | | | 29089232 | Acacetin inhibits neuronal cell death induced by 6-hydroxydopamine in cellular Parkinson's disease model |
| Allicin | 📋 | ✍ | ⛔ | | 26087780 | Allicin Protects PC12 Cells Against 6-OHDA-Induced Oxidative Stress and Mitochondrial Dysfunction via Regulating Mitochondrial Dynamics |
| Aloe-Emodin | 📋 | | | | 37191091 | Neuroprotective effect of aloe emodin against Huntington's disease-like symptoms in R6/1 transgenic mice |
| Aloin | 📋 | | | | 35421539 | Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin |
| Anthocyanins | 📋 | ✍ | ⛔ | | 29865234 | Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function |
| Apricot | 📋 | | ⛔ | | 36212969 | Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model |
| Arctigenin | 📋 | | | | 35541453 | Neuroprotective effect of arctigenin against neuroinflammation and oxidative stress induced by rotenone |
| Astragalus Root | 📋 | ✍ | ⛔ | | 36749251 | Exploring the mechanism of astragalus membranaceus in the treatment of multiple system atrophy based on network pharmacology and molecular docking |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 35297345 | A Comprehensive Review on Preclinical Evidence Based Neuroprotective Potential of Bacopa Monnieri Against Parkinson's Disease |
| Barberry | 📋 | ✍ | ⛔ | | 24535622 | Berberine prevents nigrostriatal dopaminergic neuronal loss and suppresses hippocampal apoptosis in mice with Parkinson's disease |
| Basil | 📋 | ✍ | ⛔ | | 32883197 | Identification of Novel Phyto-chemicals from Ocimum basilicum for the Treatment of Parkinson's Disease using In Silico Approach |
| Bergamot | 📋 | ✍ | ⛔ | | 32260543 | Neuroprotective Effect of Bergamot Juice in 6-OHDA-Induced SH-SY5Y Cell Death, an In Vitro Model of Parkinson's Disease |
| Beta-Lapachone | 📋 | | | | 30739428 | Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38461353 | Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles |
| Betaine | 📋 | ✍ | ⛔ | | 37508996 | Involvement of Antioxidant and Prevention of Mitochondrial Dysfunction, Anti-Neuroinflammatory Effect and Anti-Apoptotic Effect: Betaine Ameliorates Haloperidol-Induced Orofacial Dyskinesia in Rats |
| Blackcurrant | 📋 | ✍ | ⛔ | | 29865234 | Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function |
| Blueberry | 📋 | ✍ | ⛔ | | 33648289 | Chronic feeding with 3% dried raw blueberries (V. corymbosum) reduces apomorphine-induced rotations and striatal dopaminergic loss in hemiparkinsonian rats |
| Boric Acid | 📋 | ✍ | ⛔ | | 36800846 | Investigation of the pharmacological, behavioral, and biochemical effects of boron in parkinson-indicated rats |
| Calycosin | 📋 | | | | 35204105 | Calycosin Alleviates Paraquat-Induced Neurodegeneration by Improving Mitochondrial Functions and Regulating Autophagy in a Drosophila Model of Parkinson's Disease |
| Cannabidiol Oil | 📋 | ✍ | ⛔ | | 29766748 | Medical Cannabis for Pediatric Moderate to Severe Complex Motor Disorders |
| Capsaicin | 📋 | ✍ | ⛔ | | 32537633 | Regulation of Actg1 and Gsta2 Is Possible Mechanism by Which Capsaicin Alleviates Apoptosis in Cell Model of 6-OHDA-induced Parkinson's Disease |
| Catalpol | 📋 | | | | 34216649 | Therapeutic potential of catalpol and geniposide in Alzheimer's and Parkinson's diseases: A snapshot of their underlying mechanisms |
| Chamomile | 📋 | ✍ | ⛔ | | 33824100 | Effect of M. chamomilla L. tea on chlorpromazine induced catalepsy: A neuroprotective study |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 32166553 | Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells |
| Copper | 📋 | ✍ | ⛔ | | 37800457 | Fundamental Neurochemistry Review: Copper availability as a potential therapeutic target in progressive supranuclear palsy: Insight from other neurodegenerative diseases |
| Cornus | 📋 | | | | 37393274 | Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis |
| Cranberry | 📋 | ✍ | ⛔ | | 35631155 | Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease |
| Cryptotanshinone | 📋 | | | | 36124540 | Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model |
| Diosmin | 📋 | ✍ | ⛔ | | 34656609 | The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats |
| DMAE | 📋 | ✍ | ⛔ | | 112632 | Dimethylaminoethanol (deanol): effect on apomorphine-induced stereotypy and an animal model of tardive dyskinesia |
| Eclipta Alba | 📋 | ✍ | | | 33145730 | Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson's disease |
| Emodin | 📋 | | ⛔ | | 35421539 | Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin |
| Equol | 📋 | ✍ | ⛔ | | 32761299 | Equol, a Blood-Brain Barrier Permeable Gut Microbial Metabolite of Dietary Isoflavone Daidzein, Exhibits Neuroprotective Effects against Neurotoxins Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells and Caenorhabditis elegans |
| Escin | 📋 | ✍ | ⛔ | | 24657313 | Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 36464068 | Protective effects of evening primrose oil on behavioral activities, nigral microglia and histopathological changes in a rat model of rotenone-induced parkinsonism |
| Fiber | 📋 | ✍ | ⛔ | | 38142919 | Dietary fibre confers therapeutic effects in a preclinical model of Huntington's disease |
| Genipin | 📋 | | | | 37024503 | Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage |
| Giloy | 📋 | ✍ | ⛔ | | 37579290 | Neuroprotective Effects of Tinospora cordifolia via Reducing the Oxidative Stress and Mitochondrial Dysfunction against Rotenone-Induced PD Mice |
| Ginger | 📋 | ✍ | ⛔ | | 36268117 | Elucidating the Beneficial Effects of Ginger ( Zingiber officinale Roscoe) in Parkinson's Disease |
| Gingerol | 📋 | ✍ | | | 34783140 | Protective effects of 6-gingerol on 6-hydroxydopamine-induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation |
| Ginkgolic Acid | 📋 | | | | 31654699 | Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates |
| Glutathione | 📋 | ✍ | ⛔ | | 15531136 | Restorative potential of dopaminergic grafts in presence of antioxidants in rat model of Parkinson's disease |
| Glycyrrhetinic Acid | 📋 | | | | 37436491 | 18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 35358621 | Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish |
| Grape | 📋 | | ⛔ | | 36613906 | Protective Effects of Currants ( Vitis vinifera) on Corticolimbic Serotoninergic Alterations and Anxiety-like Comorbidity in a Rat Model of Parkinson's Disease |
| Honokiol | 📋 | | | | 37637959 | Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression |
| Horse Chestnut | 📋 | ✍ | ⛔ | | 32158393 | Escins Isolated from Aesculus chinensis Bge. Promote the Autophagic Degradation of Mutant Huntingtin and Inhibit its Induced Apoptosis in HT22 cells |
| Icaritin | 📋 | | | | 33805302 | Icaritin Provides Neuroprotection in Parkinson's Disease by Attenuating Neuroinflammation, Oxidative Stress, and Energy Deficiency |
| Indian Gooseberry | 📋 | | ⛔ | | 38030098 | Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats |
| Isoquercitrin | 📋 | | | | 34047315 | The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease |
| L-Arginine | 📋 | ✍ | ⛔ | | 18058820 | Variants in the Neuronal Nitric Oxide Synthase (nNOS, NOS1) Gene Are Associated With Restless Legs Syndrome |
| L-Carnosine | 📋 | ✍ | ⛔ | | 33052927 | Carnosine suppresses neuronal cell death and inflammation induced by 6-hydroxydopamine in an in vitro model of Parkinson's disease |
| L-Methionine | 📋 | ✍ | ⛔ | | 34573099 | L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson's Disease |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 34105899 | Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinson's disease model via activating the aromatic hydrocarbon receptor pathway |
| Lauric Acid | 📋 | ✍ | | | 32863249 | Lauric acid: Its role in behavioral modulation, neuro-inflammatory and oxidative stress markers in haloperidol induced Parkinson's disease |
| Limonin | 📋 | | | | 37536186 | Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats |
| Linalool | 📋 | | ⛔ | | 38473763 | Linalool, a Fragrance Compound in Plants, Protects Dopaminergic Neurons and Improves Motor Function and Skeletal Muscle Strength in Experimental Models of Parkinson's Disease |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 35892594 | Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy |
| Magnolol | 📋 | | | | 34968163 | Magnolol attenuates the locomotor impairment, cognitive deficit, and neuroinflammation in Alzheimer's disease mice with brain insulin resistance via up-regulating miR-200c |
| Mandarin | 📋 | | | | 33808343 | A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes |
| Minerals | 📋 | | | | 37509049 | What Dietary Vitamins and Minerals Might Be Protective against Parkinson's Disease? |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 27245199 | The Isothiocyanate Isolated from Moringa oleifera Shows Potent Anti-Inflammatory Activity in the Treatment of Murine Subacute Parkinson's Disease |
| Mulberry | 📋 | | ⛔ | | 18675900 | Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity |
| Mustard | 📋 | | ⛔ | | 34856751 | Anti-Parkinson's evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals |
| NAD | 📋 | | | | 32535274 | Oxidized Nicotinamide Adenine Dinucleotide-Dependent Mitochondrial Deacetylase sirtuin-3 as a Potential Therapeutic Target of Parkinson's Disease |
| Neferine | 📋 | | | | 37921051 | Neferine exerts anti‑inflammatory activity in BV‑2 microglial cells and protects mice with MPTP‑induced Parkinson's disease by inhibiting NF‑κB activation |
| Neohesperidin | 📋 | | | | 38226659 | Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice |
| Nicotinamide | 📋 | ✍ | ⛔ | | 36428497 | Neuroprotective Effects of Nicotinamide against MPTP-Induced Parkinson's Disease in Mice: Impact on Oxidative Stress, Neuroinflammation, Nrf2/HO-1 and TLR4 Signaling Pathways |
| Olive Polyphenols | 📋 | | | | 32486023 | Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 33838094 | The effects of foot massage on hemodialysis patients' sleep quality and restless leg syndrome: a comparison of lavender and sweet orange essential oil topical application |
| Paeonol | 📋 | | | | 33995926 | Paeonol Protection Against Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease |
| Parsnip | 📋 | | ⛔ | | 32700246 | Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study |
| Parthenolide | 📋 | | | | 37048065 | Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson's Disease Model |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 35240121 | Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates |
| PEA | 📋 | ✍ | ⛔ | | 26295827 | The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson's Disease Model |
| Peppermint | 📋 | ✍ | ⛔ | | 38625964 | Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities |
| Phloretin | 📋 | | | | 36463449 | Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson's Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk |
| Phytoestrogens | 📋 | | ⛔ | | 34086550 | Dietary Phytoestrogens: Neuroprotective Role in Parkinson's Disease |
| Pistachio | 📋 | ✍ | ⛔ | | 32529399 | Amelioration of motor and non-motor deficits and increased striatal APoE levels highlight the beneficial role of pistachio supplementation in rotenone-induced rat model of PD |
| Plum | 📋 | | ⛔ | | 37783584 | Plum-blossom needle therapy for Tourette syndrome: A case report |
| Prebiotics | 📋 | ✍ | ⛔ | | 38314132 | Relationship among Parkinson's disease, constipation, microbes, and microbiological therapy |
| Pregnenolone | 📋 | ✍ | ⛔ | | 36878398 | Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease |
| Progesterone | 📋 | ✍ | ⛔ | | 36967764 | Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7) |
| Psyllium | 📋 | ✍ | ⛔ | | 18474374 | The Hydrosoluble Fiber Plantago Ovata Husk Improves Levodopa (With Carbidopa) Bioavailability After Repeated Administration |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 33759084 | Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 31987026 | An Evaluation of the Effects of Pyridoxal Phosphate in Chlorpromazineinduced Parkinsonism using Mice |
| Raspberry | 📋 | ✍ | ⛔ | | 30397021 | Identification and Microbial Production of the Raspberry Phenol Salidroside that Is Active against Huntington's Disease |
| Red Sage | 📋 | ✍ | ⛔ | | 16521109 | Salviae miltiorrhizae radix increases dopamine release of rat and pheochromocytoma PC12 cells |
| Rose Essential Oil | 📋 | | | | 36920348 | Rose essential oil diminishes dopaminergic neuron degenerations and reduces α-synuclein aggregation in Caenorhabditis elegans models of Parkinson's disease |
| Royal Jelly | 📋 | ✍ | ⛔ | | 33123309 | Apitherapy for Parkinson's Disease: A Focus on the Effects of Propolis and Royal Jelly |
| Safflower | 📋 | ✍ | ⛔ | | 35940347 | Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease rat model |
| Schisandrins | 📋 | | | | 31552591 | Schisandrin A ameliorates MPTP-induced Parkinson's disease in a mouse model via regulation of brain autophagy |
| Sesame | 📋 | ✍ | ⛔ | | 37539928 | Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells |
| Sesamin | 📋 | ✍ | | | 37539928 | Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells |
| Sesamol | 📋 | | | | 24070629 | Sesamol and naringenin reverse the effect of rotenone-induced PD rat model |
| Shogaol | 📋 | | | | 37337830 | 6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson's Disease Mouse Model |
| Spermidine | 📋 | | | | 38279557 | Effect of spermidine on long non-coding RNAs MALAT1 in a rotenone induced-rat model of Parkinson's disease |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 26119304 | Hypericum Perforatum Hydroalcoholic Extract Mitigates Motor Dysfunction and Is Neuroprotective in Intrastriatal 6-Hydroxydopamine Rat Model of Parkinson's Disease |
| Stigmasterol | 📋 | | | | 38461353 | Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles |
| Syringic Acid | 📋 | | | | 33666819 | Protective mechanism of Syringic acid in an experimental model of Parkinson's disease |
| Tannic Acid | 📋 | ✍ | ⛔ | | 37373023 | Tannic Acid Mitigates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Inflammation, Oxidative Stress, Apoptosis, and Glutamate Toxicity in Rats |
| Tea | 📋 | | | | 35527564 | Independent and Joint Associations of Tea Consumption and Smoking with Parkinson's Disease Risk in Chinese Adults |
| Tetrahydrocurcumin | 📋 | ✍ | | | 18408903 | Inhibition of Monoamine oxidase-B by the Polyphenolic Compound, Curcumin and Its Metabolite Tetrahydrocurcumin, in a Model of Parkinson's Disease Induced by MPTP Neurodegeneration in Mice |
| Theaflavins | 📋 | ✍ | | | 22138428 | Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 33043200 | Anti-Parkinson's Activity of Tribulus terrestris via Modulation of AChE, α-Synuclein, TNF-α, and IL-1β |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 36289766 | Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice |
| Turmeric | 📋 | ✍ | ⛔ | | 34426907 | Toxic Feedback Loop Involving Iron, Reactive Oxygen Species, α-Synuclein and Neuromelanin in Parkinson's Disease and Intervention with Turmeric |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 36138143 | Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson's disease mice model |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 28775706 | Riboflavin Has Neuroprotective Potential: Focus on Parkinson's Disease and Migraine |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 31212603 | Cerebral Vitamin B5 (D-Pantothenic Acid) Deficiency as a Potential Cause of Metabolic Perturbation and Neurodegeneration in Huntington's Disease |
| Vitex | 📋 | ✍ | ⛔ | | 35023027 | Experimental validation of Vitex negundo leaves hydroalcoholic extract for neuroprotection in haloperidol induced parkinson's disease in rat |
| Vitexin | 📋 | | | | 37102042 | Beneficial Role of Vitexin in Parkinson's Disease |
| Withaferin A | 📋 | | | | 33904021 | Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington's Disease |
| Withanolides | 📋 | | | | 34680087 | Effect of Ashwagandha Withanolides on Muscle Cell Differentiation |
